该剧是“永生宇宙”第二部剧，改编自Anne Rice的“梅菲尔女巫家史 Lives of the Mayfair Witches”三部曲。 故事讲述直觉敏锐的年轻神经外科医生Rowan Fielding，她发现自己是一个女巫家族意料之外的继承人。她在努力面对新获得的力量时，还必须应对一种困扰了自己家族几代人的邪恶存在。 该电视剧宇宙根据Anne Rice的“吸血鬼编年史-梅菲尔女巫”系列小说打造，制片人Mark Johnson（《绝命毒师》《风骚律师》）担任领头人，Anne生前和儿子Christopher Rice担任非编剧执行制片。
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